CORDIS Project
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This project investigates how human rhinovirus affects macrophage responses, particularly focusing on its ability to alter their function and phenotype without direct replication. By developing a model of human lung alveolar macrophage-like cells, the research aims to uncover the mechanisms behind virus-induced impairm…
A growing body of evidence suggest that viruses can modulate myeloid cells responses leading to long term impairment of monocytes/macrophages phenotypes.
Whereas for virus directly infecting macrophages, the long-term effects on these cells function and phenotype have been extensively studied, for virus infecting other cell types, the effects on macrophages have been overlooked.
Yet, recent data suggest that virus-mediated modulation of macrophages can even occurred when the virus do not replica…
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