CORDIS Project
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This project focuses on targeting tumor-associated macrophages to inhibit their migration and infiltration in cancers. By understanding the mechanisms of macrophage movement, it aims to improve cancer therapies and reduce tumor growth.
Cancer is the most common cause of death and morbidity in Europe.
New therapeutic targets to combat this disease are critical.
Across many solid cancers, poor prognosis largely correlates with the infiltration of tumour-associated macrophages (TAMs). TAMs enhance tumour progression and complicate various anticancer therapies.
Although macrophages primarily employ amoeboid migration for homeostasis and immune functions, TAMs primarily utilize mesenchymal migration.
Experiments in mice revealed th…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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