CORDIS Project
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This project investigates the role of copy number alterations (CNAs) in cancer, particularly pancreatic ductal adenocarcinoma (PDAC). Using a novel genome engineering tool called MACHETE, it aims to understand how CNAs influence tumor behavior, immune evasion, and treatment response, potentially leading to new therapeu…
Cancers arise through genetic and epigenetic alterations that drive the transformation of single cells into malignant tumors.
Among genetic changes, copy number alterations (CNAs) are recurrent chromosomal events that increase or decrease the dosage of specific regions of DNA, can affect up to 30% of a cancer cell genome, and are associated with poor clinical outcomes.
Despite their pervasiveness, the functional effects of specific CNAs on cancer phenotypes remain largely unknown, as current app…
FUNDACION PRIVADA INSTITUTO DEINVESTIGACION ONCOLOGICA DE VALL-HE
FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
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