CORDIS Project
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This project investigates how macrophages present antigens to B cells in lymph nodes and the spleen. It focuses on the molecular mechanisms and membrane proteins involved in this process, aiming to enhance understanding of B cell activation and its implications for vaccine development and autoimmune diseases.
B cell activation is triggered by antigen recognition through the B cell receptor (BCR).
It has been evidently shown that the antigen encountered in vivo by B cells is mainly membrane-bound.
However, the molecular events involved in the process of recognition are not yet undertaken.
Dr.
Batista’s lab has very recently shown that macrophages collect and concentrate particulate antigen at the lymph node, where it is then encountered and acquired by follicular B cells.
So, the principal aim of this…
CANCER RESEARCH UK LBG
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