CORDIS Project
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The MA6TCELL project investigates how m6A methylation affects the differentiation and function of CD8 T cells in cancer therapies. It aims to enhance T cell therapies by understanding the regulatory mechanisms of m6A and testing enzyme inhibitors to improve treatment efficacy.
Adoptive T cell therapies have revolutionised cancer treatment in some haematological tumours.
Despite astounding advances, patients often relapse because the transferred T cells have low persistence and they lose their effector function against cancer cells.
The prime challenge for improving T cell therapies is to decipher the mechanisms that define T cell effector function and memory formation.
The MA6TCELL project aims to disentangle this problem by defining how m6A methylation on mRNA regula…
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Netherlands, Amsterdam
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SME: No
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