CORDIS Project
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This project investigates the mechanisms of protein aggregation in neurodegenerative diseases, particularly focusing on alpha-synuclein in Parkinson's disease. It aims to understand how these proteins spread between cells and the role of lysosomes in this process.
Over the last few decades, neurodegenerative diseases (NDs) became one of the top 10 global causes of death.
The accumulation of misfolded protein aggregates in affected brain regions is a common hallmark shared by several NDs.
Misfolded alpha-synuclein (α-syn) accumulates in Parkinson’s disease (PD), the second most common ND, and recently a “prion-like” mechanism linked to the spreading of α-syn has been suggested for the pathology progression.
The Zurzolo group demonstrated that α-syn fibrils…
INSTITUT PASTEUR
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