CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project explores anabolic resistance in skeletal muscle, a condition linked to age-related muscle loss. It investigates the role of lysosomal trafficking in activating a key protein, mTORC1, to understand how this process can be influenced to improve muscle health in the elderly.
The reduced ability of skeletal muscle to grow, termed anabolic resistance (AR), is thought to be a major cause of age-associated muscle loss (sarcopenia).
At the cellular level, AR is caused by an impaired activation of the protein kinase mTORC1, which in turn blunts protein synthetic responses to anabolic stimuli.
Lysosomal trafficking is critical for the full activation of mTORC1, with the blocking of this event creating anabolic resistance in otherwise healthy cells.
However, to date, this p…
THE UNIVERSITY OF BIRMINGHAM
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
