CORDIS Project
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This project aims to understand how cells maintain lysosomal membrane integrity, particularly in cancer cells. It develops new methods to detect lysosomal leakage and explores the roles of specific proteins and drugs in stabilizing lysosomal membranes to improve cell survival.
Knowing that the lysosomes contain a powerful cocktail of hydrolases capable of digesting cells and entire tissues, it is obvious that the maintenance of lysosomal membrane integrity is of utmost importance for all cells, and especially for cancer cells with dramatically increased lysosomal activity.
Yet, the mechanisms that regulate lysosomal membrane stability have remained obscure, largely due to the lack of methods sensitive enough to detect partial lysosomal leakage and suitable for screeni…
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