CORDIS Project
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This research investigates the role of the mTORC1 complex in nutrient sensing and cell signaling at lysosomes. It aims to uncover the molecular mechanisms regulating this complex, which could have implications for understanding diseases such as diabetes and cancer.
The lysosome is a eukaryotic organelle that coordinates degradative pathways with nutrient sensing and signalling.
It therefore dictates cell growth and survival depending on nutrient availability.
Dissecting the molecular machinery that enables these functions is of key importance to cell biology.
The mTORC1 complex controls cell proliferation and metabolism by nutrient sensing at lysosomes and late endosomes (LyLEs).
Recent work from the host revealed that during nutrient starvation, mTORC1 is…
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