CORDIS Project
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This project investigates the role of the Anaplastic Lymphoma Kinase (ALK) gene in various cancers, including lymphomas and lung cancer. It aims to develop targeted therapies against ALK mutations and understand their impact on cancer progression.
The Anaplastic Lymphoma Kinase (ALK) has been discovered as the result of chromosomal translocations in Anaplastic Large Cell Lymphomas (ALCL) (Chiarle et al Nat Rev Cancer. 2008, 8:11).
In ALCL, the role of the ALK oncogenic translocations has been established in vitro and in transgenic mouse models.
Recent findings have shown ALK translocations, mutations or amplifications in other types of solid cancers, such as lung carcinoma (Soda et al.
Nature. 2007, 448:561) and neuroblastoma (Mossè et al…
UNIVERSITA DEGLI STUDI DI TORINO
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