CORDIS Project
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This research examines inflammatory signaling pathways in liver diseases using genetic targeting techniques. It aims to understand the roles of specific proteins in liver cancer development and other hepatic conditions, potentially leading to new treatment strategies.
The aim of this proposal is to examine the role of inflammatory signalling pathways in murine models of liver and biliary disease by application of conditional gene targeting using cre/loxP technology.
Previous studies have provided evidence that the NF-kB pathway and its activating kinase complex – consisting of three subunits:
IKK1, IKK2 and NEMO – are crucial regulators of liver physiology and pathology, but their differential, cell specific functions in the liver are currently only poorly un…
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