CORDIS Project
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This project investigates the spatial organization of liver cells, focusing on how different zones within the liver influence cell function. By profiling hepatocytes at high resolution, the project aims to redefine our understanding of liver zonation in health and disease.
The mammalian liver is a heterogeneous, yet highly structured organ, which performs diverse functions to maintain organismal homeostasis.
Hepatocytes operate in repeating hexagonally shaped units termed lobules that are polarized by centripetal blood flow and morphogens.
This polarized microenvironment facilitates optimal function by localizing specific processes to distinct lobule layers, a phenomenon known as ‘liver zonation’.
While zonation of some key liver functions has been known for years…
WEIZMANN INSTITUTE OF SCIENCE
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