CORDIS Project
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This project examines the function of the histone demethylase LSD1 in regulating stem cell behavior and tumor development. By using mouse models, it aims to uncover the mechanisms by which LSD1 influences obesity and cancer progression.
The identification of the first histone demethylase lysine-specific demethylase 1 (LSD1) established not only the concept of reversible histone methylation in epigenetic regulation but also translated this fundamentally novel biological observation into understanding the molecular mechanisms regulation stemness, differentiation, proliferation, and pathological growth.
To unravel in an unbiased and comprehensive manner the biological function of LSD1 in physiology and pathology, we developed LSD1…
UNIVERSITAETSKLINIKUM FREIBURG
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