CORDIS Project
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This project investigates the role of lipoxygenase enzymes in skin health and disease. By studying novel lipids produced by these enzymes, the research aims to enhance understanding of skin physiology and develop new treatments for inflammatory skin disorders.
The skin has many protective functions, acting as a barrier to physical and biological threats from the external environment while regulating water loss and body temperature.
Loss of the normal skin function results in inflammation and associated diseases such as psoriasis, alopecia and ichthyosis.
The skin is highly-enriched in lipids and fatty acids, which can be converted by lipoxygenase (LOX) enzymes to bioactive mediators, termed eicosanoids. LOXs are a family of non heme iron enzymes of wh…
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