CORDIS Project
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This project focuses on understanding the mechanisms that ensure accurate chromosome segregation during cell division, as errors can lead to cancer. By studying feedback control systems in yeast, the research aims to uncover how cells monitor and correct segregation errors.
Accurate partitioning of the genetic material during cell division is critical for genetic stability.
Defects in chromosome segregation produce aneuploidy, an unequal distribution of chromosomes between daughter cells, which is cause of developmental defects, and one of the cancer hallmarks.
To ensure error-free transmission of chromosomes, feedback control systems verify that processes at each stage of the cycle have been completed before progression into the next stage.
In particular, the spin…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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