CORDIS Project
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This project investigates how uncommitted progenitor cells in the vertebrate spinal cord acquire specific identities during development. By combining experimental techniques and computational modeling, it aims to understand the mechanisms behind cell fate decisions, which is crucial for advancing regenerative medicine.
A central problem in biology and key to realising the potential of regenerative medicine is understanding the mechanisms that produce and organize cells in the complex tissues of an embryo.
In broad terms, initially uncommitted progenitors acquire their fate in response to signals that control transcriptional programmes.
These programmes drive cells through spatial and temporal successions of states that gradually refine cell identity.
How these states are established and cell fate decisions imp…
THE FRANCIS CRICK INSTITUTE LIMITED
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