CORDIS Project
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This project investigates how proteins are synthesized and processed in the dendrites of neurons, focusing on neurotransmitter receptors and ion channels. By using genetic engineering and biochemical techniques, it aims to understand local protein turnover and glycosylation, which are crucial for regulating dendritic e…
The local synthesis and degradation of proteins represent a particularly efficient means to adaptively modify the composition of targeted dendritic branches and associated synapses.Recent data from our laboratory show that numerous mRNA encoding neurotransmitter receptors and voltage-gated channels are enriched in distal dendrites, indicating that local translation sustains local membrane protein turnover and may thus regulate dendritic excitability.
In contrast to cytoplasmic proteins, local p…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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