CORDIS Project
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This project explores the use of ionizable lipid nanoparticles to induce immune tolerance rather than immunity. By incorporating antigens in a non-immunogenic way, it aims to broaden the application of these nanoparticles in treating allergies and autoimmune diseases.
The recent success of ionizable lipid nanoparticles (iLNPs) as vehicles for mRNA (mRNA-iLNP) as a safe and highly effective vaccine in the protection against SARS-CoV-2 pushed the lipid nanoparticle technology to the forefront of medicine and launched worldwide interest in their potential as a therapeutic vaccine against numerous pathogens or tumor antigens.
Still, their mode of action remains largely a black box.
One of the most remarkable properties of mRNA-LNPs is that they do not require any…
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