CORDIS Project
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This project focuses on developing advanced 3D culture systems to study hepatitis B virus infection. By using human pluripotent stem cells, the aim is to create better models for testing antiviral drugs and understanding the virus's behavior in liver cells.
An estimated ~400 million people are chronically infected with hepatitis B virus (HBV) infection worldwide, resulting in an estimated $658 million in medical costs and lost wages annually.
Although HBV disease can be prevented by vaccination, many people still become infected.
Potent and safe drugs are available to eradicate HBV viral particles and clinically ‘cure’ HBV infection.
However, during replication HBV delivers a very stable form of viral DNA (covalently closed circular DNA, cccDNA) in…
KATHOLIEKE UNIVERSITEIT LEUVEN
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