CORDIS Project
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This project investigates the liver's complex cellular organization and functionality by analyzing single hepatocytes within their natural environment. It aims to understand how spatial zonation and cell characteristics, such as polyploidy, contribute to liver performance and metabolic regulation.
The mammalian liver performs critical functions for maintaining metabolic homeostasis.
It regulates the body’s glucose and lipid stores, detoxifies blood, and produces bile among a host of other functions.
The liver achieves this diversity through the collective behaviour of heterogeneous hepatocytes operating in highly structured microenvironments.
Understanding the design principles of the liver is an open challenge requiring analysis of single cells within the intact tissue.Liver heterogeneit…
WEIZMANN INSTITUTE OF SCIENCE
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