CORDIS Project
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This project investigates lipid flippases, specifically ATP8B1, which transport phospholipids across cell membranes. It aims to understand the regulation and function of ATP8B1, particularly its role in inherited intrahepatic cholestasis, a severe liver disease affecting children.
Lipid flippases mediate transport of phospholipids from the exoplasmic leaflet to the cytosolic one, and their role is to establish and maintain phospholipid asymmetry in eukaryotic membranes.
This asymmetry is tightly regulated and it is implicated in numerous cellular processes such as membrane trafficking, signaling, blood coagulation, apoptosis, cytokinesis, or cell fusion.
The human genome encodes 14 different P4-ATPases, a subset of them being linked to pathologies such as mental retardati…
AARHUS UNIVERSITET
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