CORDIS Project
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This project focuses on enhancing cancer immunotherapy by normalizing tumor stiffness using engineered live biotherapeutics. These programmable bacteria deliver enzymes to improve blood flow and oxygen supply in tumors, potentially increasing the effectiveness of immune checkpoint inhibitors in treating colorectal and…
Immunotherapy, including immune checkpoint inhibitors (ICIs), has revolutionized the treatment of multiple cancers.
Anti-tumor responses are often durable but overall only a subset of patients receiving ICIs has exhibited sustained tumor shrinkage, whereas a substantial fraction receiving these therapies develops immune-related adverse events.
The absence of dramatic responses is attributed to several factors, including abnormalities in the tumor microenvironment (TME).
Specifically, many tumors…
UNIVERSITY OF CYPRUS
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