CORDIS Project
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The project investigates the mechanisms of transcriptional adaptation during early zebrafish development, focusing on how gene expression is regulated in response to genetic mutations. It aims to understand the spatial and temporal characteristics of this process at the single-cell level.
The development of a multicellular organism requires the precise control of gene expression in space and time so that cells adopt their correct identity.
However, genetic mutations can alter this complex process.
Recently, transcriptional adaptation (TA) has been uncovered as one of the mechanisms underlying genetic compensation in zebrafish, mouse cells in culture, and Caenorhabditis elegans. TA refers to the phenomenon by which mutated genes (often with mRNA-destabilizing mutations) trigger…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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