CORDIS Project
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This project investigates the role of phosphatidylserine in synaptic pruning during brain development. By examining how this lipid signal influences the interaction between synapses and microglia, the research aims to uncover mechanisms behind synapse elimination, which is crucial for proper neural circuit formation an…
The development of the nervous system is associated with the generation of excess neuronal synapses that is followed by their tightly controlled removal, a process known as synaptic pruning.
In the primate cortex, for example, 70% of connections are selectively lost within the first six months of life.
Why are so many synapses lost, what determines which synapses are eliminated, what are the molecular mechanisms involved, and what are the consequences of not getting it right?
Recently, several s…
VILNIAUS UNIVERSITETAS
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