CORDIS Project
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This project investigates small open reading frames (smORFs) and their potential role in lipid metabolism in response to dietary excess. By exploring the effects of specific food components, it aims to uncover novel peptides that could provide insights into cardiovascular disease mechanisms and innovative dietary strat…
Dietary excess is the major origin of cardiovascular diseases and remains the leading cause of mortality.
Due to difficulties with bioinformatics detection and experimental analysis, along with their sheer numbers, small open reading frames (smORF) –of fewer than 100 amino acids– have been largely disregarded.
Advances in bioinformatics, RNA-sequencing (ribosome profiling), biochemical (peptidomics) and functional (genetic) screens, suggest that a large amount of smORF are transcribed and someti…
FUNDACION IMDEA ALIMENTACION
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United States, La Jolla
Type: Research institute
Activity type: Research Organisations
SME: No
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