CORDIS Project
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This project focuses on enhancing the delivery of mRNA vaccines by optimizing lipid nanoparticles with mannose ligands to improve uptake by dendritic cells. By utilizing DNA origami for precise ligand organization, the project aims to advance vaccine efficacy against viruses, cancer, and genetic diseases.
mRNA vaccines have gained considerable attentions in prevention and treatment of virus infections, cancer and genetic diseases, especially in the application to the COVID-19 pandemic in recent years.
Due to the immunogenicity and instability of mRNA, the in vivo delivery of mRNA plays a crucial role in vaccine efficacy.
Among various materials, lipid nanoparticles (LNPs) have shown to be one of the most potent carriers for mRNA delivery and successfully enter the clinic.
To further improve vacci…
KAROLINSKA INSTITUTET
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