CORDIS Project
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This project investigates the immune response to Hepatitis B virus by analyzing the function and characteristics of CD4 T cells and B cells in both acute and chronic infections. The goal is to identify immune markers that correlate with protection and impairment, utilizing patient samples and advanced immunological tec…
Hepatitis B virus (HBV), an hepatotropic non-cytopathic DNA virus, still represents a global health problem, with million of deaths for year because of complication of chronic infection.
Chronic infection and its outcome are believed a consequence of defective antiviral response, mainly in T-cell arm, probably mediated by prolonged exposition to large amounts of viral antigens.
Recently, many advancements have been done on virus-specific CD8 dysfunction or “exhaustion”, while far less is known a…
FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
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