CORDIS Project
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This project investigates the role of linear ubiquitin chains in cellular processes such as NF-κB signaling, autophagy, apoptosis, and DNA repair. By understanding these mechanisms, the research aims to uncover their implications in diseases like cancer and inflammation, and identify potential drug targets.
Ubiquitin (Ub) is a small modifier that labels proteins in a highly specific manner.
Like phosphorylation, modification of proteins by Ub is prevalent in the majority of cellular processes.
An increasing number of distinct functions have been assigned to different types of ubiquitin modifications (monoUb and different Lys-linked chains).
Moreover, aberrations in the ubiquitin system underlie many disease states, including cancer, inflammatory, immune and metabolic disorders as well as neurodegen…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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