CORDIS Project
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This project investigates the role of LINE-1, a type of mobile DNA, in human somatic cells and its implications for diseases. It aims to understand how LINE-1 activity affects genetic stability and contributes to conditions like cancer, potentially guiding therapeutic strategies.
45% of the human genome is made of repeated DNA, and some types can be mobilized within the genome (mobile DNA). LINE-1 or L1 is the only autonomous active mobile DNA within the human genome, with 500.000 copies per haploid genome (~17% of the genome).
Overall, L1 is responsible for ~30% of our genome.
Due to its activity and number in the genome, the impact that L1 has and have on the genome is notable. L1 mobility can result in several human diseases (due to insertions within genes) and can al…
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD M.P.
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