CORDIS Project
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This research focuses on the LIM domain proteins LASP1 and PDLIM4, which are linked to the actin cytoskeleton and various diseases. The project aims to clarify their roles in cellular structures and signaling pathways, potentially revealing new insights into disease mechanisms, particularly in cancer.
The LIM domain proteins LASP1 and PDLIM4 are associated with the actin cytoskeleton, and implicated in many diseases.
However, their precise molecular functions are poorly understood.
Recent protein interaction studies from my host laboratory provided evidence that these two proteins associate with stress fibers (SFs), the contractile actomyosin structures of non-muscle cells.
Distant homologues of LASP1 and PDLIM4 are also present in muscle sarcomeres, suggesting a potential structural role of…
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