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The Elongator project explores the role of a protein complex in regulating gene expression during light responses in plants. It focuses on understanding how this complex influences cell growth and signaling pathways related to light, which is crucial for plant development.
Elongator is a histone acetyltransferase (HAT) complex associated with RNA polymerase II (RNAPII) to facilitate transcription elongation.
It consists of subunits Elp1-6 with Elp3 conferring HAT activity.
Elongator is conserved in yeast, plants and humans.
In humans, mutations in Elp genes cause neuronal diseases.
In plants, Elongator is a positive regulator of cell proliferation during leaf and root growth.
Elongator mutants have altered auxin signaling and responses to abscisic acid.
Elongator…
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