CORDIS Project
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This research project aims to identify and characterize factors that contribute to leukemia in hematopoietic cells using a specialized mouse model. By generating a retroviral cDNA library from leukemia cells, the study seeks to uncover novel cellular factors that could serve as potential therapeutic targets for leukemi…
The proposed research aims to identify and characterize factors conferring leukemic properties to hematopoietic cells.
This screen will be based upon a murine leukemia model I have developed in my time at the Salk Institute (La Jolla, CA) these mice express a fusion of RARalpha with three FKBP12 Rapamycin-regulated dimerization domains” FKBP12 F36M (F3-RARa).
These F3-RARa TG mice, though healthy, exhibit a “preleukemic” state that is more accessible to transformation by cellular factors, such a…
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
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