CORDIS Project
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This project evaluates the division of B cells in Chronic Lymphocytic Leukemia using deuterium labeling to track DNA synthesis. It aims to identify different cell populations within the disease, enhancing understanding of its biology and informing targeted therapies.
B cell Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in western countries.
Although substantial therapeutic improvements have been obtained, the disease is incurable and causes 4000 deaths/year in the sole USA.We plan to in vivo evaluate CLL B cells division by measuring Deuterium (2H) incorporation into newly synthesized DNA. 2H given to patients in the form of deuterated water (2H2O) is a very practical, safe, non invasive approach that has been already exploited in CLL patien…
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