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The LEUKEMIABARRIER project investigates the early stages of acute myeloid leukemia (AML) using a transgenic mouse model. It aims to identify molecular factors that determine why some hematopoietic progenitor cells develop into AML and how immune responses influence this progression.
Acute myeloid leukemia (AML) is the most common malignant myeloid disorder in adults and strongly associated in incidence to advanced age. AML arises from immature hematopoietic progenitor cells via a sequential multistep process, but the nature of these steps remains to a large extent unknown.
Therefore, while significant efforts have previously been invested in characterizing the molecular properties of late-stage AML, as diagnosed in patients, less information is available on the events that…
MAX IV Laboratory, Lund University
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