CORDIS Project
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This project investigates the potential of leptin as an alternative treatment for Type 1 diabetes mellitus. By studying its effects on specific hypothalamic neurons, it aims to uncover mechanisms that could lead to safer therapies without the risks associated with insulin.
Type 1 diabetes mellitus (T1DM) is caused by pancreatic β-cell loss.
The sole life-saving intervention available to the millions affected by T1DM is insulin therapy.
Unfortunately, this therapy does not restore normal metabolic homeostasis and as a result the life-expectancy and -quality of T1DM people is worse than the ones of normal subjects.
In part, this is due to challenging morbidities of T1DM, as for example heart disease and hypoglycemia, both of which are thought to be caused by insulin…
UNIVERSITE DE GENEVE
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