CORDIS Project
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This project investigates the role of leptin, a hormone linked to fat storage, in autoimmune diseases like multiple sclerosis. It aims to understand how leptin influences regulatory T cells and their potential implications for treating autoimmune conditions.
Our Group has been investigating the cellular and molecular mechanisms involving leptin, the adipocyte-derived hormone, in the pathogenesis of autoimmunity such as experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).We analyzed the serum and cerebro-spinal fluid (CSF) leptin secretion and the interaction between serum leptin and naturally occurring Foxp3+CD4+CD25+ regulatory T cells (Tregs) in naïve-to-therapy multiple sclerosis (MS) patients.
Leptin production was signif…
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