CORDIS Project
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This project investigates how leukocytes polarize during inflammation, focusing on the signals from blood vessel cells that trigger this process. Using advanced imaging techniques, it aims to characterize the interactions between leukocytes and platelets, enhancing our understanding of inflammation and its impact on he…
During the inflammatory response, leukocytes accumulate in the vascular lumen and undergo a morphological and molecular polarization characterized by the formation of discrete domains (a leading edge and an uropod) that allows their directional migration.
We aim to understand how and when this polarization originates, as well as the endothelial signals that induce it under physiological conditions.
We propose to use a novel intravital microscopy system to image these domains in real-time.
Recent…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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