CORDIS Project
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This project focuses on developing synthetic lectins to improve the identification and separation of biomolecules modified with O-GlcNAc, a carbohydrate linked to various diseases. The research aims to create advanced biological tools through international collaboration, enhancing techniques in supramolecular chemistry…
Lectins are carbohydrate-binding proteins which play many roles in nature, and are important also as tools for biological research.
For example, they are used to make fluorescent reagents which bind to, and thus identify, particular carbohydrate units, and also to make separation media which distinguish between differently glycosylated biomolecules.
An important target for such reagents/media is beta-GlcNAc on serine or threonine (the O-GlcNAc protein modification).
This moiety has been implicat…
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