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The LC-FMRI project investigates the role of the locus coeruleus in brain function using optogenetic stimulation and advanced imaging techniques. It aims to understand how this brain region influences overall brain dynamics and neurovascular coupling, with potential implications for neurodegenerative disorders.
Locus coeruleus (LC) regulates vital autonomous and cognitive functions and has recently gained interest as a clinical target in neurodegenerative and psychiatric disorders.
Previous studies have investigated the effect of LC activity on small groups of neurons and on endpoint behavior.
However, LC’s widespread connections and broad downstream effects make a systems-level approach imperative for comprehensively understanding LC function.
In LC-FMRI, we will perform highly specific optogenetic LC…
FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
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