CORDIS Project
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This project investigates how reducing insulin/IGF signaling can protect against toxic protein aggregation associated with neurodegenerative diseases like Alzheimer's. By studying the nematode C. elegans and mice, it aims to identify key factors and genes that mediate stress resistance and longevity, potentially leadin…
Aberrant protein aggregation (proteotoxicity) is an underlying mechanistic event common to numerous late-onset human neurodegenerative maladies including Alzheimer’s (AD) disease.
Recent studies indicated that the ageing process plays key roles in enabling protein aggregation to become toxic late in life.
The insulin/IGF signaling pathway (IIS) is a major ageing, stress resistance and lifespan regulator in worms and mice.
We found that IIS reduction protects worms and mice from toxicity associat…
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