CORDIS Project
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The project focuses on developing a novel method for constructing cyclopropane rings from C–H bonds in various chemical compounds, including complex drug molecules. This innovative approach aims to enhance the discovery of cyclopropane-based drugs, addressing unmet medical needs through improved metabolic stability and…
The cyclopropane ring is the 10th most commonly observed core in small-molecule drugs.
This is due to the fact that cyclopropanes can positively influence metabolic stability, conformation, pKa, entropy, membrane permeability or pharmacokinetics in drug leads.
The cyclopropane ring is often introduced in drug candidates at the early stages of the synthesis, however, the late-stage construction of multi-substituted cyclopropanes using C–H bonds as a functional group has not been developed yet.
Th…
FUNDACION PRIVADA INSITUTO CATALAN DE INVESTIGACION QUIMICA ICIQ
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
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