CORDIS Project
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This project develops advanced nuclear magnetic resonance spectroscopy techniques to measure lactate distribution in the brain. By focusing on the differences in lactate diffusion among cell types, it aims to enhance understanding of brain metabolism, particularly in the context of neurodegenerative diseases like Alzhe…
The idea has emerged that compartmentation of brain lactate, i.e. its distribution between different cell types and the extracellular space, plays a critical role in neurotransmission and brain plasticity.
Dysregulations of lactate metabolism have also been reported in neurodegenerative diseases such as Alzheimer's disease.
However, these notions remain challenged, and even fundamental mechanisms such as the astrocyte-to-neuron lactate shuttle, whereby astrocytes are supposed to export lactate t…
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