CORDIS Project
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The project aims to develop an artificial protein container to deliver ribonucleic acids into mammalian cells for gene therapy. By engineering a protein-based system, it seeks to enhance the efficiency of delivering therapeutic RNA, potentially improving treatments for diseases caused by dysfunctional proteins.
Nucleic acids are promising candidates for treating disease by stimulating, inhibiting, or replacing other nucleic acids or proteins inside of eukaryotic cells—a process known as “gene therapy.” However, methods to efficiently and safely deliver genes into cells are still lacking.
The problem is that nucleic acids are not cell permeant and degrade before reaching the cytosol.
One way to transport oligonucleotides into cells is by packaging them into hollow containers made of proteins, a method t…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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