CORDIS Project
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This project aims to improve kidney transplantation outcomes by investigating the role of genetic factors beyond HLA mismatches. It will utilize advanced bioinformatics and genomics to understand immune responses and enhance graft survival.
Chronic renal failure affects ~10% of the world population and can gradually lead to end-stage renal disease (ESRD) requiring kidney transplantation.
Despite the huge progress of immunosuppressive treatments, the host immune response against the graft still leads to rejection in many cases, with an average graft half-life of 10 years.
Triggers leading to graft rejection are still largely unknown and need to be studied beyond the well-recognized impact of HLA mismatches.I propose here to explore…
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