CORDIS Project
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This project aims to understand the structure and function of inwardly rectifying potassium channels, specifically the KirBac3.1 channel, using cryo electron crystallography. By determining the channel's structure in both open and closed states, the project seeks to elucidate the mechanisms of ion transport across cell…
Ion channels, proteins that allow the passage of ions across the membrane, have crucial roles in many important physiological processes, such as nerve and muscle excitation, cell proliferation, hormone secretion and blood pressure regulation.
Thus, defects in their function cause serious diseases.
Moreover, their position on the cell surface, their heterogeneity and the localized expression in particular tissues make ion channels an attractive target for many drug therapies.
The study of structu…
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