CORDIS Project
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This project investigates how the organization of microtubules in neurons affects the transport of kinesin motor proteins. By mapping the microtubule network and using optogenetics, the project aims to enhance understanding of polarized transport, which is crucial for brain function and may have implications for neurod…
The human brain consists of intricately connected neurons forming functional circuits encoding memory, emotions and cognition. A neuron’s polarized organisation into axons and dendrites underlies its ability to receive, process and transmit information.
To establish and maintain such a highly complex organisation, cytoskeletal motor proteins transport basic building blocks to either axons or dendrites.
Several members of the kinesin motor family are selectively moving into axons, presumably guid…
UNIVERSITEIT UTRECHT
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