CORDIS Project
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This project investigates the activation of cytotoxic T-cells in the immune response against cancer. It aims to improve vaccine design by studying the processes that lead to T-cell activation, focusing on the role of dendritic cells and peptide presentation.
The activation of The activation of cytotoxic T-cells (CTLs) marks the key step in the adaptive immune response against cancer and viral infections.
Vaccines that activate the CTL-response against tumours are currently hotly pursued, with those targeting tumour-specific mutations now reaching the clinic.
However, the capacity of these vaccines to actually activate CTLs is low and rational design improvements are needed to broaden their application.
For this, better in vivo knowledge on the proce…
UNIVERSITEIT LEIDEN
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