CORDIS Project
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This project explores the potential of mouse embryonic stem cells to differentiate into renal cell types for treating end-stage renal disease. It aims to assess their ability to improve kidney function in a rodent model of kidney injury and develop a tracking system for monitoring the cells post-transplantation.
The number of people world-wide with end-stage renal disease (ESRD) is increasing every year.
Current treatment options consist of dialysis and transplantation, both of which have significant side effects in terms of quality and quantity of life.
Therefore there is an urgent need to develop alternative therapies.
My recent work has shown that if mouse embryonic stem cells (mESC) are directed to differentiate to mesodermal cells, they show high potential for integrating into developing nephrons i…
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