CORDIS Project
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This project focuses on kinase proteins, crucial for cell signaling, and aims to develop selective inhibitors targeting inactive forms of these proteins. Using advanced computational techniques, it seeks to understand binding mechanisms to enhance drug discovery for cancer therapies.
Kinase proteins are key to signaling in eukaryotic cells, so it is not surprising that their dysfunction has been implicated in human diseases such as cancer and inflammatory disorders.
As a result, kinases have become important targets for drug discovery.
The majority of kinase inhibitors bind to the ATP-binding site, which is highly conserved among the different kinases.
In order to increase inhibitor selectivity toward a desired target kinase, the focus has turned to developing inhibitors…
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FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain, Madrid
Type: Research institute
Activity type: Research Organisations
SME: No
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