CORDIS Project
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The KetoCardio project investigates the role of ketones in heart failure with preserved ejection fraction (HFpEF). It aims to understand how ketones function as energy sources and influence cardiomyocyte signaling and gene expression, potentially leading to new therapeutic strategies for this condition.
Heart failure with preserved ejection fraction (HFpEF) is a burgeoning public health problem for which there are little to no evidence-based therapies.
This syndrome has proven particularly challenging because of the limited insight into its underlying molecular mechanisms.
Metabolic adaptations are critical for cardiomyocyte response to stress.
Ketones are metabolites actively produced in heart failure and their role as metabolic rheostat capable of modulating cardiac metabolism and cardiomyocy…
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